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Institutsseminare

 

Prof. Kristina Sepčič

Department of Biology, Biotechnical Faculty, University of Ljubljana

Aegerolysin proteins: interactions with lipid membranes and potential applications

Host:Prof. Benoît Zuber
 26.06.2018, 12:00, Seminar room A263, Institute of Anatomy
 Sandwiches and drinks will be served
 Selected publications Butala M, Novak M, Kraševec N, Skočaj M, Veranič P, Maček P, Sepčić K. Aegerolysins: lipid-binding proteins with versatile functions. Semin Cell Dev Biol. Available online 12 May 2017 Botić T, Defant A, Zanini P, Žužek MC, Frangež R, Janussen D, Kersken D, Knez Ž, Mancini I, Sepčić K. Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors. Eur J Med Chem 136:294-304. Skočaj M, Yu Y, Grundner M, Resnik N, Bedina Zavec A, Leonardi A, Križaj I, Guella G, Maček P, Erdani Kreft M, Frangež R, Veranič R, Sepčić K. Characterisation of plasmalemmal shedding of vesicles induced by the cholesterol/sphingomyelin binding protein, ostreolysin A-mCherry. Biochim Biophys Acta 1858: 2882–2893. Koss DJ, Robinson L, Mietelska-Porowska A, Gasiorowska A, Sepčić K, Turk T, Jaspars M, Niewiadomska G, Scott RH, Platt B, Riedel G. Polymeric alkylpyridinium salts permit intracellular delivery of human Tau in rat hippocampal neurons: requirement of Tau phosphorylation for functional deficits. Cell. Mol. Life Sci. 72:4613–4632. Skočaj M, Resnik N, Grundner M, Ota K, Rojko N, Hodnik V, Anderluh G, Sobota A, Maček P, Veranič P, Sepčič K. Tracking cholesterol/sphingomyelin-rich membrane domains with the ostreolysin A-mCherry protein. PloS one. 2014:9: e92783. Mesarič T, Baweja L, Drašler B, Drobne D, Makovec D, Dušak P, Dhawan A, Sepčić K. Effects of surface curvature and surface characteristics of carbon-based nanomaterials on the adsorption and activity of acetylcholinesterase. Carbon (N. Y.). [Print ed.], 2013, vol. 62, str. 222-232, doi: 10.1016/j.carbon.2013.05.060.

 

Dr. Marco Osterwalder

Laboratory A. Visel and L. Pennacchio, Lawrence Berkeley National Laboratory

Belt and Suspenders: Enhancer Redundancy in Mammalian Genomes

Host:Prof. Nadia Mercader
 28.06.2018, 12:00, Seminar room A263, Institute of Anatomy
 Selected publications: 1. Osterwalder, M., Barozzi, I., Tissières, V., Fukuda-Yuzawa, Y., Mannion, B.J., Afzal, S., Lee, E.A., Zhu, Y., Plajzer-Frick, I., Pickle, C.S., Kato, M., Garvin, T.H., Pham, Q.T., Harrington, A.N., Akiyama, J.A., Afzal, V., Lopez-Rios, J., Dickel, D.E., Visel, A., Pennacchio, L.A. (2018). Enhancer Redundancy Provides Phenotypic Robustness in Mammalian Development. Nature 554(7691):239-243. Pubmed ID 29420474 Featured in Science (after presentation as speaker at The Biology of Genomes meeting in 2016) 2. Osterwalder, M., Speziale, D., Shoukry, M., Mohan, R., Ivanek, R., Kohler, M., Beisel, C., Wen, X., Scales, S. J., Christoffels, V. M., Visel, A., Lopez-Rios, J., Zeller, R. (2014). HAND2 targets define a network of transcriptional regulators that compartmentalize the early limb bud mesenchyme. Developmental Cell 31(3):345-357. Pubmed ID 25453830 3. Osterwalder, M., Galli, A., Rosen, B., Skarnes, W.C., Zeller, R., Lopez-Rios, J. (2010). Dual RMCE for efficient re-engineering of mouse mutant alleles. Nature Methods 7(11), 893-895. Pubmed ID 20953177 Featured in "The author file" in Nature Methods (2010) and highlighted by Faculty of 1000 Biology.